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Harnessing mismatch repair to model sporadic cancers

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Two mouse models that initiate sporadic tumors seek to recapitulate spontaneously arising human cancers.

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Figure 1: Two mouse models designed to recapitulate the initial sporadic mutation step(s) of tumorigenesis.

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Authors and Affiliations

  1. Richard Fishel and Joanna Groden are in the Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, Ohio 43210, USA. rfishel@osu.edu or groden.2@osu.edu,

    Richard Fishel & Joanna Groden

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  1. Richard Fishel
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  2. Joanna Groden
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Fishel, R., Groden, J. Harnessing mismatch repair to model sporadic cancers. Nat Methods 5, 225–226 (2008). https://doi.org/10.1038/nmeth0308-225

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