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The mysteries of induced pluripotency: where will they lead?

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The discovery that it is possible to render somatic cells pluripotent by the exogenous expression of a set of transcription factors provides an experimental model for studying the molecular nature of cellular identity.

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Figure 1: The epigenetic landscape proposed by C.H. Waddington.
Figure 2: 'Secondary' fibroblasts isolated from chimeric embryos made with iPS cells respond efficiently to reprogramming factor induction.
Figure 3: Proposed phases, transition points and cell fates during reprogramming to iPS cells.

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Authors and Affiliations

  1. Mount Sinai Hospital and the Department of Molecular Genetics, Andras and Kristina Nagy are at the Samuel Lunenfeld Research Institute, University of Toronto, Toronto, Ontario, Canada

    Andras Nagy & Kristina Nagy

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  1. Andras Nagy
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  2. Kristina Nagy
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Correspondence to Andras Nagy or Kristina Nagy.

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Nagy, A., Nagy, K. The mysteries of induced pluripotency: where will they lead?. Nat Methods 7, 22–24 (2010). https://doi.org/10.1038/nmeth.f.292

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