Skip to main content
SpringerLink
Log in

Induced pluripotent stem cell technology for the study of human disease

  • Commentary
  • Published:

From Nature Methods

View current issue Submit your manuscript

iPS cell technology makes patient- and disease-specific human cells widely available. While technical challenges still remain, the use of these tools will greatly expand our understanding of human disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: iPSCs for studying human disease.
Figure 2: An artistic representation of iPSC-based human disease modeling.

References

  1. Wilmut, I., Schnieke, A.E., McWhir, J., Kind, A.J. & Campbell, K.H. Nature 385, 810–813 (1997).

    Article  CAS  Google Scholar 

  2. Wakayama, T. et al. Science 292, 740–743 (2001).

    Article  CAS  Google Scholar 

  3. Munsie, M.J. et al. Curr. Biol. 10, 989–992 (2000).

    Article  CAS  Google Scholar 

  4. Verlinsky, Y. et al. Reprod. Biomed. Online 10, 105–110 (2005).

    Article  CAS  Google Scholar 

  5. Eiges, R. et al. Cell Stem Cell 1, 568–577 (2007).

    Article  CAS  Google Scholar 

  6. Mateizel, I. et al. Hum. Reprod. 21, 503–511 (2006).

    Article  CAS  Google Scholar 

  7. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    Article  CAS  Google Scholar 

  8. Okita, K., Ichisaka, T. & Yamanaka, S. Nature 448, 313–317 (2007).

    Article  CAS  Google Scholar 

  9. Wernig, M. et al. Nature 448, 318–324 (2007).

    Article  CAS  Google Scholar 

  10. Zhao, X.Y. et al. Nature 461, 86–90 (2009).

    Article  CAS  Google Scholar 

  11. Kang, L., Wang, J., Zhang, Y., Kou, Z. & Gao, S. Cell Stem Cell 5, 135–138 (2009).

    Article  CAS  Google Scholar 

  12. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  Google Scholar 

  13. Yu, J. et al. Science 318, 1917–1920 (2007).

    Article  CAS  Google Scholar 

  14. Park, I.H. et al. Cell 134, 877–886 (2008).

    Article  CAS  Google Scholar 

  15. Dimos, J.T. et al. Science 321, 1218–1221 (2008).

    Article  CAS  Google Scholar 

  16. Soldner, F. et al. Cell 136, 964–977 (2009).

    Article  CAS  Google Scholar 

  17. Ebert, A.D. et al. Nature 457, 277–280 (2009).

    Article  CAS  Google Scholar 

  18. Lee, G. et al. Nature 461, 402–406 (2009).

    Article  CAS  Google Scholar 

  19. Axelrod, F.B. Expert Opin. Pharmacother. 6, 561–567 (2005).

    Article  CAS  Google Scholar 

  20. Ye, Z. et al. Blood published online, doi: 10.1182/blood-2009-04-217406 (1 October 2009)

  21. Placantonakis, D.G. et al. Stem Cells 27, 521–532 (2009).

    Article  CAS  Google Scholar 

  22. Hockemeyer, D. et al. Nat. Biotechnol. 27, 851–857 (2009).

    Article  CAS  Google Scholar 

  23. Di Giorgio, F.P., Carrasco, M.A., Siao, M.C., Maniatis, T. & Eggan, K. Nat. Neurosci. 10, 608–614 (2007).

    Article  CAS  Google Scholar 

  24. Nagai, M. et al. Nat. Neurosci. 10, 615–622 (2007).

    Article  CAS  Google Scholar 

  25. Raya, A. et al. Nature 460, 53–59 (2009).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. and Lorenz Studer is also in the Department of Neurosurgery; Sloan-Kettering Institute, Gabsang Lee and Lorenz Studer are in the Developmental Biology Program, New York, New York, USA.,

    Gabsang Lee & Lorenz Studer

  2. Sloan-Kettering Institute, New York, New York, USA.,

    Gabsang Lee & Lorenz Studer

Authors
  1. Gabsang Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lorenz Studer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Lorenz Studer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, G., Studer, L. Induced pluripotent stem cell technology for the study of human disease. Nat Methods 7, 25–27 (2010). https://doi.org/10.1038/nmeth.f.283

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.f.283

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation