An intermediate cell state of chemical reprogramming can be induced to convert directly between cell types.
References
Li, X. et al. Direct reprogramming of fibroblasts via a chemically induced XEN-like state. Cell Stem Cell 21, 264–273.e7 (2017).
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Nawy, T. Many paths from a XEN-like state. Nat Methods 14, 834–835 (2017). https://doi.org/10.1038/nmeth.4419
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DOI: https://doi.org/10.1038/nmeth.4419
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