Combining an inducible methyltransferase with a methylation-sensitive zinc finger creates an epigenetic memory circuit.
References
Maier, J.A.H. et al. Design of synthetic epigenetic circuits featuring memory effects and reversible switiching based on DNA methylation. Nat. Commun. 8, 15336 (2017).
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Rusk, N. Synthetic epigenetic memory. Nat Methods 14, 764 (2017). https://doi.org/10.1038/nmeth.4382
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DOI: https://doi.org/10.1038/nmeth.4382
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