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Genomics

Another player for RNA-guided RNA cleavage

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Cas13b relies on activator and repressor proteins to regulate RNA cleavage.

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References

  1. Shmakov, S. et al. Diversity and evolution of class 2 CRISPR–Cas systems. Nat. Rev. Microbiol. http://dx.doi.org/10.1038/nrmicro.2016.184 (2017).

  2. Burstein, D. et al. New CRISPR–Cas systems from uncultivated microbes. Nature http://dx.doi.org/10.1038/nature21059 (2016).

  3. Smargon, A.A. et al. Cas13b is a type VI-B CRISPR associated RNA-guided RNase differentially regulated by Csx27 and Csx28. Mol. Cell. http://dx.doi.org/10.1016/j.molcel.2016.12.023 (2017).

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Authors
  1. Nicole Rusk
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Rusk, N. Another player for RNA-guided RNA cleavage. Nat Methods 14, 222–223 (2017). https://doi.org/10.1038/nmeth.4213

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  • DOI: https://doi.org/10.1038/nmeth.4213

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