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Genetic screening enters the single-cell era

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Four studies overcome the limitations of pooled and arrayed genetic screens by integrating single-cell transcriptomics.

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Figure 1: Massively parallel genetic screening using pooled CRISPR perturbations and scRNA-seq.

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Author notes

  1. Daniel E Wagner and Allon M Klein: Daniel E. Wagner and Allon M. Klein are members of the Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA.

Authors and Affiliations

  1. Daniel E. Wagner is a Howard Hughes Medical Institute Fellow of the Life Sciences.,

    Daniel E Wagner & Allon M Klein

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  1. Daniel E Wagner
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  2. Allon M Klein
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Correspondence to Allon M Klein.

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Competing interests

A.M.K. is a founder and member of the SAB of 1Cell-Bio.

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Wagner, D., Klein, A. Genetic screening enters the single-cell era. Nat Methods 14, 237–238 (2017). https://doi.org/10.1038/nmeth.4196

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