Skip to main content
SpringerLink
Log in

The quest for multiplexed spatially resolved transcriptional profiling

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

Crowded transcript signals are resolved by cross-correlation or by gel expansion microscopy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Resolving fluorescent signals from densely packed RNA molecules.

References

  1. Chen, K.H., Boettiger, A.N., Moffitt, J.R., Wang, S. & Zhuang, X. Science 348, aaa6090 (2015).

    Article  Google Scholar 

  2. Ke, R. et al. Nat. Methods 10, 857–860 (2013).

    Article  CAS  Google Scholar 

  3. Lubeck, E. et al. Nat. Methods 11, 360–361 (2014).

    Article  CAS  Google Scholar 

  4. Lee, J.H. et al. Science 343, 1360–1363 (2014).

    Article  CAS  Google Scholar 

  5. Coskun, A.F. & Cai, L. Nat. Methods 13, 657–660 (2016).

    Article  CAS  Google Scholar 

  6. Chen, F. et al. Nat. Methods 13, 679–684 (2016).

    Article  CAS  Google Scholar 

  7. Chen, F., Tillberg, P.W. & Boyden, E.S. Science 347, 543–548 (2015).

    Article  CAS  Google Scholar 

  8. Kolin, D.L. & Wiseman, P.W. Cell Biochem. Biophys. 49, 141–164 (2007).

    Article  CAS  Google Scholar 

  9. Clausson, C.M. et al. Sci. Rep. 5, 12317 (2015).

    Article  Google Scholar 

  10. Clausson, C.M. et al. Nat. Methods 8, 892–893 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Department of Information Technology and the Science for Life Laboratory, Carolina Wählby is at the Centre for Image Analysis, Uppsala University, Uppsala, Sweden.,

    Carolina Wählby

Authors
  1. Carolina Wählby
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Carolina Wählby.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wählby, C. The quest for multiplexed spatially resolved transcriptional profiling. Nat Methods 13, 623–624 (2016). https://doi.org/10.1038/nmeth.3924

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.3924

  • Springer Nature America, Inc.

Search

Navigation