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The ORFeome Collaboration: a genome-scale human ORF-clone resource

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Figure 1: RefSeq and Ensembl genes and functional gene categories represented in the OC.

References

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Acknowledgements

The authors acknowledge valuable encouragement for initiating the OC from F. Collins (US National Institutes of Health) and E. Harlow (Harvard Medical School). Some of the cDNAs used as PCR templates for ORF cloning and other support were received from the German cDNA Consortium: K. Köhrer (University Düsseldorf, Germany), W. Ansorge (EMBL Heidelberg, Germany), H. Blöcker (Helmholtz Center Braunschweig, Germany), W. Mewes, C. Amid (Helmholtz Center Munich, Germany), J. Lauber, A. Bahr (Qiagen, Hilden, Germany), D. Heubner, R. Wambutt (Agowa, Berlin, Germany), B. Ottenwälder, B. Obermaier (Medigenomix, Ebersberg, Germany), H. Blum, H. Domdey (University Munich, Germany), I. Schupp, S. Bechtel and A. Poustka (DKFZ, Heidelberg, Germany). The German cDNA Consortium was funded by the Federal Ministry of Education and Research (BMBF) in the frame of the German Genome Project (DHGP) and the German National Genome Research Network (NGFN) programs (to S.W.). This work was supported by the Ellison Foundation (grant to M.V. and D.E.H.); the DFCI Institute (Sponsored Research funds to M.V. and D.E.H.); the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (research grants to Y.H. at the RIKEN Omics Science Center and to P.C. at the RIKEN Center for Life Science Technologies); and the MEXT Genome Network Project (grant to Y.H.).

Author information

Author notes

  1. UC Santa Cruz Genomics Institute, University of California, Santa Cruz, California, USA.

Authors and Affiliations

  1. Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Stefan Wiemann, Anika Jöcker & Ruth Wellenreuther

  2. Genomics & Proteomics Core Facility, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Stefan Wiemann, Oliver Heil & Agnes Hotz-Wagenblatt

  3. IMAGE Consortium, Lawrence Livermore National Laboratories, Livermore, California, USA

    Christa Pennacchio

  4. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Yanhui Hu

  5. Virginia G. Piper Center for Personalized Diagnostics (VGPCPD), Biodesign Institute, Arizona State University, Tempe, Arizona, USA

    Preston Hunter, Jin Park, Catherine Seiler, Jason Steel & Joshua LaBaer

  6. DNAFORM Inc., Tsurumi-ku, Yokohama City, Kanagawa, Japan

    Matthias Harbers

  7. Division of Genomic Technologies, RIKEN Center for Life Science Technologies, RIKEN Yokohama Institute, Tsurumi-ku, Yokohama, Kanagawa, Japan

    Matthias Harbers & Piero Carninci

  8. Dharmacon, GE Healthcare, Lafayette, Colorado, USA

    Alexandra Amiet & Anja van Brabant Smith

  9. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK

    Graeme Bethel & Ian Dunham

  10. Source BioScience, Nottingham, UK

    Melanie Busse & Tom Weaver

  11. Center for Cancer Systems Biology (CCSB), Dana‐Farber Cancer Institute, Boston, Massachusetts, USA

    Tong Hao, Kourosh Salehi-Ashtiani, Marc Vidal & David E Hill

  12. Department of Cancer Biology, Dana‐Farber Cancer Institute, Boston, Massachusetts, USA

    Tong Hao, Kourosh Salehi-Ashtiani, Marc Vidal & David E Hill

  13. Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA

    Tong Hao, Kourosh Salehi-Ashtiani, Marc Vidal & David E Hill

  14. Dana-Farber–Harvard Cancer Center (DFHCC) DNA Resource Core and Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA

    J Wade Harper

  15. RIKEN Preventive Medicine & Diagnosis Innovation Program, RIKEN Yokohama Institute, Wako, Saitama, Japan

    Yoshihide Hayashizaki & Jun Kawai

  16. imaGenes GmbH, Berlin, Germany

    Steffen Hennig, Christoph Koenig & Johannes Maurer

  17. National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA

    Wonhee Jang & Lukas Wagner

  18. Ressourcenzentrum für Genomforschung gGmbH, Berlin, Germany

    Bernhard Korn

  19. National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA

    Cristen Lambert & Gary Temple

  20. HudsonAlpha Institute of Biotechnology, Huntsville, Alabama, USA

    Anita LeBeau & Blake Simmons

  21. GeneCopoeia, Inc., Rockville, Maryland, USA

    Sun Lu & Shuwei Yang

  22. Guangzhou FulenGen, Ltd., Guangdong, China

    Sun Lu

  23. Open Biosystems, Inc., Huntsville, Alabama, USA

    Troy Moore & Blake Simmons

  24. Kasusa DNA Research Institute, Kisarazu, Chiba, Japan

    Osamu Ohara

  25. Department of Biological Chemistry & Molecular Pharmacology, Harvard Institute of Proteomics, Harvard Medical School, Boston, Massachusetts, USA

    Andreas Rolfs

  26. Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Daniela S Gerhard

  27. Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona, USA

    Joshua LaBaer

Consortia

The ORFeome Collaboration

  • Stefan Wiemann
  • , Christa Pennacchio
  • , Yanhui Hu
  • , Preston Hunter
  • , Matthias Harbers
  • , Alexandra Amiet
  • , Graeme Bethel
  • , Melanie Busse
  • , Piero Carninci
  • , Ian Dunham
  • , Tong Hao
  • , J Wade Harper
  • , Yoshihide Hayashizaki
  • , Oliver Heil
  • , Steffen Hennig
  • , Agnes Hotz-Wagenblatt
  • , Wonhee Jang
  • , Anika Jöcker
  • , Jun Kawai
  • , Christoph Koenig
  • , Bernhard Korn
  • , Cristen Lambert
  • , Anita LeBeau
  • , Sun Lu
  • , Johannes Maurer
  • , Troy Moore
  • , Osamu Ohara
  • , Jin Park
  • , Andreas Rolfs
  • , Kourosh Salehi-Ashtiani
  • , Catherine Seiler
  • , Blake Simmons
  • , Anja van Brabant Smith
  • , Jason Steel
  • , Lukas Wagner
  • , Tom Weaver
  • , Ruth Wellenreuther
  • , Shuwei Yang
  • , Marc Vidal
  • , Daniela S Gerhard
  • , Joshua LaBaer
  • , Gary Temple
  •  & David E Hill

Corresponding authors

Correspondence to Stefan Wiemann, Matthias Harbers, Marc Vidal, Joshua LaBaer, Gary Temple or David E Hill.

Ethics declarations

Competing interests

Various coauthors work in companies that license, manufacture and sell research reagents including the ORF clones derived from human genes that are described in this manuscript. The following authors are commercial distributors of OC clones and thus declare competing financial interests: M.H., A.A., M.B., S.H., C.K., B.K., A.L., S.L., J.M., T.M., B.S., A.v.B.S., T.W. and S.Y.

Supplementary information

Supplementary Text

Supplementary Note (PDF 776 kb)

Supplementary Data

Background and structure of OC; description of OC clone collection; evaluation of gene coverage in functional categories; how to obtain OC clones; the OC clone annotation process. (PDF 6194 kb)

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The ORFeome Collaboration. The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat Methods 13, 191–192 (2016). https://doi.org/10.1038/nmeth.3776

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