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Single in the (Cell) City: a protein-folding story

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An integrated single-molecule fluorescence approach enables the study of nano-to-millisecond protein conformational dynamics in living mammalian cells.

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Figure 1: In vivo single-molecule protein dynamics.

Debbie Maizels/Nature Publishing Group

References

  1. Lord, S.J., Lee, H.L. & Moerner, W.E. Anal. Chem. 82, 2192–2203 (2010).

    Article  CAS  Google Scholar 

  2. Li, G.W. & Xie, X.S. Nature 475, 308–315 (2011).

    Article  CAS  Google Scholar 

  3. Ha, T. et al. Proc. Natl. Acad. Sci. USA 93, 6264–6268 (1996).

    Article  CAS  Google Scholar 

  4. König, I. et al. Nat. Methods 12, 773–779 (2015).

    Article  Google Scholar 

  5. Ebbinghaus, S., Dhar, A., McDonald, J.D. & Gruebele, M. Nat. Methods 7, 319–323 (2010).

    Article  CAS  Google Scholar 

  6. Sakon, J.J. & Weninger, K.R. Nat. Methods 7, 203–205 (2010).

    Article  CAS  Google Scholar 

  7. Crawford, R. et al. Biophys. J. 105, 2439–2450 (2013).

    Article  CAS  Google Scholar 

  8. Hoffmann, A. et al. Phys. Chem. Chem. Phys. 13, 1857–1871 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Physics, Anne Plochowietz and Achillefs N. Kapanidis are at the Clarendon Laboratory, University of Oxford, Oxford, UK.,

    Anne Plochowietz & Achillefs N Kapanidis

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  1. Anne Plochowietz
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  2. Achillefs N Kapanidis
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Correspondence to Anne Plochowietz or Achillefs N Kapanidis.

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The authors declare no competing financial interests.

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Plochowietz, A., Kapanidis, A. Single in the (Cell) City: a protein-folding story. Nat Methods 12, 715–716 (2015). https://doi.org/10.1038/nmeth.3491

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