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Genome engineering: the next genomic revolution

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A decade of advances in genome engineering technologies has enabled the editing of genome sequences much like one edits computer code; many more applications for precisely manipulating genome structure and function are on the horizon.

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Figure 1: Applications of genome-editing technologies.

Kim Caesar/Nature Publishing Group

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Acknowledgements

I thank the members of the Gersbach laboratory and our collaborators that have contributed to our work in this area. C.A.G. is supported by US National Institutes of Health (NIH) Director's New Innovator Award (DP2OD008586), US National Science Foundation (NSF) Faculty Early Career Development (CAREER) Award (CBET-1151035), NIH R01DA036865, NIH R21AR065956 and the Muscular Dystrophy Association (MDA277360).

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Authors and Affiliations

  1. Charles A. Gersbach is in the Department of Biomedical Engineering and at the Center for Genomic and Computational Biology, and in the Department of Orthopaedic Surgery, Duke University, Duke University Medical Center, Durham, North Carolina, USA.,

    Charles A Gersbach

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  1. Charles A Gersbach
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Correspondence to Charles A Gersbach.

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Competing interests

C.A.G. is an inventor on patent applications related to genome engineering and a scientific advisor to Editas Medicine, a company engaged in therapeutic development of genome engineering tools.

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Gersbach, C. Genome engineering: the next genomic revolution. Nat Methods 11, 1009–1011 (2014). https://doi.org/10.1038/nmeth.3113

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