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Gene targeting with nucleases: capped templates, semper fidelis?

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Use of adenoviral vectors to deliver donor templates for genome editing facilitates precise genome modifications in human cells. This has implications for both basic and translational applications of rare-cleaving nuclease technologies.

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  1. Andrew Scharenberg is at Seattle Children's Research Institute, Seattle, Washington, USA.,

    Andrew Scharenberg

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  1. Andrew Scharenberg
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Correspondence to Andrew Scharenberg.

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Yes there is potential Competing Interest.

I have equity in Bluebird Bio. I am on the Bluebird Bio Scientific Advisory Board, and consult for Bluebird Bio.

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Scharenberg, A. Gene targeting with nucleases: capped templates, semper fidelis?. Nat Methods 11, 1029–1030 (2014). https://doi.org/10.1038/nmeth.3110

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