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KinomeXplorer: an integrated platform for kinome biology studies

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Figure 1: Overview of the improved NetworKIN algorithm in KinomeXplorer.

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Acknowledgements

We would like to thank members of R.L.'s laboratory for useful input on the manuscript, and A. Pasculescu for input on the data collection. This work was supported by the Lundbeck Foundation, the Human Frontier Science Program (HFSP), the Danish Council for Independent Research (FSS) and the European Research Council (ERC).

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Author notes

  1. Heiko Horn, Erwin M Schoof and Jinho Kim: These authors contributed equally to this work.

Authors and Affiliations

  1. Novo Nordisk Foundation Center for Protein Research, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark

    Heiko Horn & Lars Juhl Jensen

  2. Department of Systems Biology, Cellular Signal Integration Group (C-SIG), Center for Biological Sequence Analysis (CBS), Technical University of Denmark (DTU), Lyngby, Denmark

    Erwin M Schoof, Jinho Kim, Xavier Robin & Rune Linding

  3. Computational Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    Martin L Miller

  4. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany

    Francesca Diella

  5. Molecular Health GmbH, Heidelberg, Germany

    Francesca Diella

  6. Department of Biology, University of Rome Tor Vergata, Rome, Italy

    Anita Palma & Gianni Cesareni

  7. Istituto Ricovero e Cura a Carattere Scientifico, Fondazione Santa Lucia, Rome, Italy

    Gianni Cesareni

Authors
  1. Heiko Horn
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  2. Erwin M Schoof
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  3. Jinho Kim
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  4. Xavier Robin
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  5. Martin L Miller
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  6. Francesca Diella
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  7. Anita Palma
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  8. Gianni Cesareni
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  9. Lars Juhl Jensen
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  10. Rune Linding
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Corresponding authors

Correspondence to Lars Juhl Jensen or Rune Linding.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Text and Figures

Supplementary Figures 1 and 2, and Supplementary Note (PDF 757 kb)

Supplementary Table 1

Benchmark of the NetworKIN method (XLS 44 kb)

Supplementary Table 2

Dataset for training NetPhorest and NetworKIN (XLS 3640 kb)

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Horn, H., Schoof, E., Kim, J. et al. KinomeXplorer: an integrated platform for kinome biology studies. Nat Methods 11, 603–604 (2014). https://doi.org/10.1038/nmeth.2968

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