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Making connections: using networks to stratify human tumors

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Network-based stratification (NBS) enables the subtyping of tumors on the basis of their mutational profiles, providing new avenues for cancer research and precision oncology.

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References

  1. Chin, L., Andersen, J.N. & Futreal, P.A. Nat. Med. 17, 297–303 (2011).

    Article  CAS  Google Scholar 

  2. Sotiriou, C. & Piccart, M.J. Nat. Rev. Cancer 7, 545–553 (2007).

    Article  CAS  Google Scholar 

  3. Hofree, M., Shen, J.P., Carter, H., Gross, A. & Ideker, T. Nat. Methods 10, 1108–1115 (2013).

    Article  CAS  Google Scholar 

  4. Vogelstein, B. et al. Science 339, 1546–1558 (2013).

    Article  CAS  Google Scholar 

  5. Vandin, F., Upfal, E. & Raphael, B.J. J. Comput. Biol. 18, 507–522 (2011).

    Article  CAS  Google Scholar 

  6. Ein-Dor, L., Zuk, O. & Domany, E. Proc. Natl. Acad. Sci. USA 103, 5923–5928 (2006).

    Article  CAS  Google Scholar 

  7. Venet, D., Dumont, J.E. & Detours, V. PLoS Comput. Biol. 7, e1002240 (2011).

    Article  CAS  Google Scholar 

  8. Cole, C. et al. Cancer Biol. Ther. 10, 495–504 (2010).

    Article  CAS  Google Scholar 

  9. Greenman, C., Wooster, R., Futreal, P.A., Stratton, M.R. & Easton, D.F. Genetics 173, 2187–2198 (2006).

    Article  CAS  Google Scholar 

  10. Lawrence, M.S. et al. Nature 499, 214–218 (2013).

    Article  CAS  Google Scholar 

  11. Tomasetti, C., Vogelstein, B. & Parmigiani, G. Proc. Natl. Acad. Sci. USA 110, 1999–2004 (2013).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Benjamin J. Raphael is in the Department of Computer Science and Center for Computational Molecular Biology Brown University, Providence, Rhode Island, USA.,

    Benjamin J Raphael

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  1. Benjamin J Raphael
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Correspondence to Benjamin J Raphael.

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The author declares no competing financial interests.

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Raphael, B. Making connections: using networks to stratify human tumors. Nat Methods 10, 1077–1078 (2013). https://doi.org/10.1038/nmeth.2704

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