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Visualizing networks of mobility in proteins

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An algorithm called CONTACT identifies correlated side-chain motions in proteins from X-ray crystallographic data, providing insights into dynamics and function.

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Figure 1: Using clashes to determine correlated motions.

References

  1. van den Bedem, H. et al. Nat. Methods 10, 896–902 (2013).

    Article  CAS  Google Scholar 

  2. Fraser, J.S. et al. Proc. Natl. Acad. Sci. USA 108, 16247–16252 (2011).

    Article  CAS  Google Scholar 

  3. Lang, P.T. et al. Protein Sci. 19, 1420–1431 (2010).

    Article  CAS  Google Scholar 

  4. Fraser, J.S. et al. Nature 462, 669–673 (2009).

    Article  CAS  Google Scholar 

  5. Schnell, J.R., Dyson, H.J. & Wright, P.E. Annu. Rev. Biophys. Biomol. Struct. 33, 119–140 (2004).

    Article  CAS  Google Scholar 

  6. Adamczyk, A.J. et al. Proc. Natl. Acad. Sci. USA 108, 14115–14120 (2011).

    Article  CAS  Google Scholar 

  7. Bhabha, G. et al. Science 332, 234–238 (2011).

    Article  CAS  Google Scholar 

  8. Caspar, D.L. et al. Nature 332, 659–662 (1988).

    Article  CAS  Google Scholar 

  9. Wall, M.E., Ealick, S.E. & Gruner, S.M. Proc. Natl. Acad. Sci. USA 94, 6180–6184 (1997).

    Article  CAS  Google Scholar 

  10. Wall, M.E. Methods Mol. Biol. 544, 269–279 (2009).

    Article  CAS  Google Scholar 

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Correspondence to Mark A. Wilson.

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Wilson, M. Visualizing networks of mobility in proteins. Nat Methods 10, 835–837 (2013). https://doi.org/10.1038/nmeth.2606

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