Skip to main content
SpringerLink
Log in

Protein instability following transport or storage on dry ice

  • Correspondence
  • Published:

From Nature Methods

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Effect of dry ice on pH and aggregation index.

References

  1. Manning, M.C., Chou, D.K., Murphy, B.M., Payne, R.W. & Katayama, D.S. Pharm. Res. 27, 544–575 (2010).

    Article  Google Scholar 

  2. Shire, S.J., Cromwell, M. & Liu, J. AAPS J. 8, E729–E730 (2006).

    Article  Google Scholar 

  3. Philo, J.S. & Arakawa, T. Curr. Pharm. Biotechnol. 10, 348–351 (2009).

    Article  CAS  Google Scholar 

  4. Rosenberg, A.S. AAPS J. 8, E501–E507 (2006).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Legacy BioDesign LLC, Johnstown, Colorado, USA

    Brian M Murphy & Mark C Manning

  2. Department of Chemistry, Colorado State University, Fort Collins, Colorado, USA

    Brian M Murphy & Mark C Manning

  3. Department of Chemistry and Biochemistry, San Diego State University, San Diego, California, USA

    Spencer Swarts & Peter van der Geer

  4. Torrey Pines Institute for Molecular Studies, San Diego, California, USA

    Barbara M Mueller

  5. Somatek Inc., San Diego, California, USA

    Mark I Fitchmun

  6. Accelagen Inc., San Diego, California, USA

    Mark I Fitchmun

Authors
  1. Brian M Murphy
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Spencer Swarts
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Barbara M Mueller
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Peter van der Geer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Mark C Manning
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mark I Fitchmun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Mark I Fitchmun.

Ethics declarations

Competing interests

B.M. Murphy and M.C.M. performed research related to this manuscript while employed by Legacy BioDesign. M.I.F. performed research related to this manuscript while employed by Somatek.

Supplementary information

Supplementary Text and Figures

Supplementary Tables 1 and 2 and Supplementary Methods (PDF 184 kb)

CO2-induced acidification of sample upon thaw

Acidification is seen as a color shift from yellow to red starting at the sample-headspace interface. (MOV 443 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Murphy, B., Swarts, S., Mueller, B. et al. Protein instability following transport or storage on dry ice. Nat Methods 10, 278–279 (2013). https://doi.org/10.1038/nmeth.2409

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.2409

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation