Skip to main content
Log in

Tracking genomic hydroxymethylation by the base

  • News & Views
  • Published:

From Nature Methods

View current issue Submit your manuscript

An Erratum to this article was published on 29 April 2013

This article has been updated

A method uses single-molecule, real-time DNA sequencing to detect the modified base 5-hydroxymethylcytosine, an epigenetic mark recently suspected of having essential roles in genome regulation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: 5-hmC detection by SMRT sequencing.

Change history

  • 18 February 2013

    In the version of this article initially published, ref. 1 contained an incorrect volume number and year. The errors have been corrected in the HTML and PDF versions of the article.

References

  1. Song, C.-X. et al. Nat. Methods 9, 75–77 (2012).

    Article  CAS  Google Scholar 

  2. Penn, N.W., Suwalski, R., O'Riley, C., Bojanowski, K. & Yura, R. Biochem. J. 126, 781–790 (1972).

    Article  CAS  Google Scholar 

  3. Tahiliani, M. et al. Science 324, 930–935 (2009).

    Article  CAS  Google Scholar 

  4. Quivoron, C . et al. Cancer Cell 20, 25–38 (2011).

    Article  CAS  Google Scholar 

  5. Gu, T.P. et al. Nature 477, 606–610 (2011).

    Article  CAS  Google Scholar 

  6. Ficz, G. et al. Nature 473, 398–402 (2011).

    Article  CAS  Google Scholar 

  7. Kriaucionis, S. & Heintz, N. Science 324, 929–930 (2009).

    Article  CAS  Google Scholar 

  8. Huang, Y. et al. PLoS ONE 5, e8888 (2010).

    Article  Google Scholar 

  9. Pastor, W.A. et al. Nature 473, 394–397 (2011).

    Article  CAS  Google Scholar 

  10. Song, C.X. et al. Nat. Biotechnol. 29, 68–72 (2011).

    Article  CAS  Google Scholar 

  11. Flusberg, B.A. et al. Nat. Methods 7, 461–465 (2010).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Gilles Salbert or Michael Weber.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Salbert, G., Weber, M. Tracking genomic hydroxymethylation by the base. Nat Methods 9, 45–46 (2012). https://doi.org/10.1038/nmeth.1813

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nmeth.1813

  • Springer Nature America, Inc.

This article is cited by

Navigation