Chromatin immunoprecipitation and yeast one-hybrid systems are complementary approaches to identify protein-DNA interactions. Improvements to these methods now make them more versatile and high-throughput, and should lead to the generation of rich datasets for the study of gene regulation.
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References
Mazzoni, E.O. et al. Nat. Methods 8, 1056–1058 (2011).
Gaudinier, A. et al. Nat. Methods 8, 1053–1055 (2011).
Reece-Hoyes, J.S. et al. Nat. Methods 8, 1050–1052 (2011).
Hens, K. et al. Nat. Methods 8, 1065–1070 (2011).
Reece-Hoyes, J.S. et al. Nat. Methods 8, 1059–1064 (2011).
Johnson, D.S. et al. Science 316, 1497–1502 (2007).
Deplancke, B. et al. Genome Res. 14, 2093–2101 (2004).
Ni, J.Q. et al. Nat. Methods 8, 405–407 (2011).
Yuh, C.H. et al. Science 279, 1896–1902 (1998).
Clyde, D.E. et al. Nature 426, 849–853 (2003).
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Ozdemir, A., Stathopoulos, A. Exciting times: bountiful data to facilitate studies of cis-regulatory control. Nat Methods 8, 1016–1017 (2011). https://doi.org/10.1038/nmeth.1795
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DOI: https://doi.org/10.1038/nmeth.1795
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