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On target? Tracing zinc-finger-nuclease specificity

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In two independent studies, researchers experimentally test the cleavage specificity of zinc-finger nucleases across the genome.

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Figure 1: Strategies to determine nuclease off-target sites.

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Authors and Affiliations

  1. Claudio Mussolino and Toni Cathomen are at the Institute of Experimental Hematology, Hannover Medical School, Hannover, Germany.,

    Claudio Mussolino & Toni Cathomen

Authors
  1. Claudio Mussolino
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  2. Toni Cathomen
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Correspondence to Toni Cathomen.

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The authors declare no competing financial interests.

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Mussolino, C., Cathomen, T. On target? Tracing zinc-finger-nuclease specificity. Nat Methods 8, 725–726 (2011). https://doi.org/10.1038/nmeth.1680

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