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Protein polymers

Encoding phase transitions

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Intrinsically disordered protein polymers can be designed to encode tunable lower or upper critical solution temperatures in physiological solutions.

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Figure 1: A two-component mixture can exist as a well-mixed, one-phase system, or as a two-phase system where the two components segregate into polymer-rich and solvent-rich phases.

References

  1. Li, P. et al. Nature 483, 336–340 (2012).

    Article  CAS  Google Scholar 

  2. Yeo, G. C., Keeley, F. W. & Weiss, A. S. Adv. Colloid Interface Sci. 167, 94–103 (2011).

    Article  CAS  Google Scholar 

  3. Weber, S. C. & Brangwynne, C. P. Curr. Biol. 25, 641–646 (2015).

    Article  CAS  Google Scholar 

  4. Quiroz, F. G. & Chilkoti, A. Nature Mater. 14, 1164–1171 (2015).

    Article  CAS  Google Scholar 

  5. Nott, T. J. et al. Mol. Cell 57, 936–947 (2015).

    Article  CAS  Google Scholar 

  6. Holehouse, A. S., Garai, K., Lyle, N., Vitalis, A. & Pappu, R. V. J. Am. Chem. Soc. 137, 2984–2995 (2015).

    Article  CAS  Google Scholar 

  7. Das, R. K., Ruff, K. M. & Pappu, R. V. Curr. Opin. Struct. Biol. 32, 102–112 (2015).

    Article  CAS  Google Scholar 

  8. Decker, C. J., Teixeira, D. & Parker, R. J. Cell Biol. 179, 437–449 (2007).

    Article  CAS  Google Scholar 

  9. Brangwynne, C. P. et al. Science 324, 1729–1732 (2009).

    Article  CAS  Google Scholar 

  10. Kato, M. et al. Cell 149, 753–767 (2012).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Alex S. Holehouse and Rohit V. Pappu are in the Department of Biomedical Engineering and Center for Biological Systems Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, USA,

    Alex S. Holehouse & Rohit V. Pappu

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  1. Alex S. Holehouse
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  2. Rohit V. Pappu
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Correspondence to Rohit V. Pappu.

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Holehouse, A., Pappu, R. Encoding phase transitions. Nature Mater 14, 1083–1084 (2015). https://doi.org/10.1038/nmat4459

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