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Puncturing cells en masse

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Porous silicon nanoneedles efficiently puncture cell monolayers, delivering biomolecules into cells both in vitro and in vivo.

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Figure 1: Nanoneedle-mediated intracellular delivery.

References

  1. Zhang, Y. Methods Mol. Biol. 853, 169–176 (2012).

    Article  CAS  Google Scholar 

  2. Waehler, R., Russell, S. J. & Curiel, D. T. Nature Rev. Genet. 8, 573–587 (2007).

    Article  CAS  Google Scholar 

  3. Wang, W. et al. Curr. Pharm. Biotechnol. 14, 46–60 (2013).

    CAS  Google Scholar 

  4. Chiappini, C. et al. Nature Mater. 14, 532–539 (2015).

    Article  CAS  Google Scholar 

  5. Yum, K., Yu, M. F., Wang, N. & Xiang, Y. K. Biochim. Biophys. Acta 1810, 330–338 (2011).

    Article  CAS  Google Scholar 

  6. Yan, L., Yang, Y., Zhang, W. & Chen, X. Adv Mater. 26, 5533–5540 (2014).

    Article  CAS  Google Scholar 

  7. Bae, H. et al. Sci. Transl. Med. 4, 160ps23 (2012).

    Article  Google Scholar 

  8. Rettig, G. R. & Behlke, M. A. Mol. Ther. 20, 483–512 (2012).

    Article  CAS  Google Scholar 

  9. Meacham, J. M., Durvasula, K., Degertekin, F. L. & Fedorov, A. G. J. Lab Autom. 19, 1–18 (2014).

    Article  CAS  Google Scholar 

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Correspondence to Mark R. Prausnitz.

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Prausnitz, M. Puncturing cells en masse. Nature Mater 14, 470–471 (2015). https://doi.org/10.1038/nmat4274

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