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Stem cell mechanics

Auxetic nuclei

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The nuclei of naive mouse embryonic stem cells that are transitioning towards differentiation expand when the cells are stretched and contract when they are compressed. What drives this auxetic phenotype is, however, unclear.

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Figure 1: The nucleus of an embryonic stem cell in the transition state expands when stretched.

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Authors and Affiliations

  1. Ning Wang is in the Department of Biomedical Engineering, and the Department of Mechanical Science and Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA,

    Ning Wang

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  1. Ning Wang
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Correspondence to Ning Wang.

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Wang, N. Auxetic nuclei. Nature Mater 13, 540–542 (2014). https://doi.org/10.1038/nmat3987

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