DNA-complexated cationic polymers with reduced charge density, high molecular weight and increased hydrophobicity show a lack of detectable cytotoxicity and efficiently deliver the apoptosis-inducing TRAIL gene to transplanted tumours in mice.
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Mastrobattista, E., Hennink, W. Charged for success. Nature Mater 11, 10–12 (2012). https://doi.org/10.1038/nmat3209
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DOI: https://doi.org/10.1038/nmat3209
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