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Protein folding

To knot or not to knot?

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A knot-containing protein is found to fold reversibly at biologically relevant timescales despite not having naturally evolved for this ability.

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Figure 1: Knots in proteins.
Figure 2: Unknotted (top) and knotted (bottom) twin proteins.

References

  1. Taylor, W. R. Nature 406, 916–919 (2000).

    Article  CAS  Google Scholar 

  2. Mallam, A. L. & Jackson, S. E. J. Mol. Biol. 366, 650–65 (2007).

    Article  CAS  Google Scholar 

  3. Mallam, A. L., Morris, E. R. & Jackson, S. E. Proc. Natl Acad. Sci. USA 105, 18740–18745 (2008).

    Article  CAS  Google Scholar 

  4. Wallin, S., Zeldovich, K. B. & Shakhnovich, E. I. J. Mol. Biol. 368, 884–893 (2007).

    Article  CAS  Google Scholar 

  5. Sulkowska, J. I., Sulkowski, P. & Onuchic, J. Proc. Natl Acad. S ci. USA 106, 3119–3124 (2009).

    Article  CAS  Google Scholar 

  6. King, N. P., Jacobitz, A. W., Sawaya, M. R., Goldschmidt, L. & Yeates, T. O. Proc. Natl Acad. Sci. USA 107, 20732–20737 (2010).

    Article  CAS  Google Scholar 

  7. Virnau, P., Mirny, L. A. & Kardar, M. PLoS Comput. Biol. 2, e122 (2006).

    Article  Google Scholar 

  8. Shakhnovich, E. I. Phys. Rev. Lett. 72, 3907–3910 (1994).

    Article  CAS  Google Scholar 

  9. Kuhlman, B. et al. Science 302, 1364–1368 (2003).

    Article  CAS  Google Scholar 

  10. Dahiyat, B. I. & Mayo, S. L. Science 278, 82–87 (1997).

    Article  CAS  Google Scholar 

  11. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  Google Scholar 

  12. Grosberg, A., Nechaev, S. K. & Shakhnovich, E. I. J. Phys. (France) 49, 2095–2100 (1988).

    Article  CAS  Google Scholar 

  13. Lua, R. C. & Grosberg, A. Y. PLoS Comput. Biol. 2, e45 (2006).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Eugene Shakhnovich is at the Department of Chemistry, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA. shakhnovich@chemistry.harvard.edu,

    Eugene Shakhnovich

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  1. Eugene Shakhnovich
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Shakhnovich, E. To knot or not to knot?. Nature Mater 10, 84–86 (2011). https://doi.org/10.1038/nmat2953

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