Sustained gene knockdown by the aid of a well-known biodegradable polymer has shown that old materials can still be used to solve new problems.
References
Fire, A. et al. Nature 391, 806–811 (1997).
Whitehead, K. A., Langer, R. & Anderson, D. G. Nature Rev. Drug Discov. 8, 129–138 (2009).
Woodrow, K. A. et al. Nature Mater. 8, 526–533 (2009).
Kumar, P. et al. Cell 134, 577–586 (2008).
Palliser, D. et al. Nature 439, 89–94 (2006).
Gu, W. et al. Cancer Gene Ther. 13, 1023–1032 (2006).
Putney, S. D. & Burke, P. A. Nature Biotech. 16, 153–157 (1998).
Luo, D., Woodrow-Mumford, K., Belcheva, N. & Saltzman, W. M. Pharm. Res. 16, 1300–1308 (1999).
Cu, Y. & Saltzman, W. M. Mol. Pharm. 6, 173–181 (2009).
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Campolongo, M., Luo, D. Old polymer learns new tracts. Nature Mater 8, 447–448 (2009). https://doi.org/10.1038/nmat2456
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DOI: https://doi.org/10.1038/nmat2456
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