Skip to main content
SpringerLink
Log in

Crippling SWI-SNF makes tumors GLI-ful

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The chromatin remodeling complex SWI-SNF is altered in cancer. New findings now show that the core component SNF5 can block a Hedgehog (Hh) effector, which promotes malignant rhabdoid tumor growth when SNF5 is lost (pages 1429–1433). Targeting this Hh effector may be a way to combat these aggressive childhood tumors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Loss of SNF5 allows misexpression of GLI1 in MRT.

Marina Corral

References

  1. Tamkun, J.W. et al. Cell 68, 561–572 (1992).

    Article  CAS  Google Scholar 

  2. Versteege, I. et al. Nature 394, 203–206 (1998).

    Article  CAS  Google Scholar 

  3. Lee, D. et al. J. Biol. Chem. 277, 22330–22337 (2002).

    Article  CAS  Google Scholar 

  4. Cheng, S.W. et al. Nat. Genet. 22, 102–105 (1999).

    Article  CAS  Google Scholar 

  5. Roberts, C.W., Galusha, S.A., McMenamin, M.E., Fletcher, C.D. & Orkin, S.H. Proc. Natl. Acad. Sci. USA 97, 13796–13800 (2000).

    Article  CAS  Google Scholar 

  6. Zhang, Z.K. et al. Mol. Cell. Biol. 22, 5975–5988 (2002).

    Article  CAS  Google Scholar 

  7. Gresh, L. et al. EMBO J. 24, 3313–3324 (2005).

    Article  CAS  Google Scholar 

  8. Jagani, Z. et al. Nat. Med. 16, 1429–1433 (2010).

    Article  CAS  Google Scholar 

  9. Nilsson, M. et al. Proc. Natl. Acad. Sci. USA 97, 3438–3443 (2000).

    Article  CAS  Google Scholar 

  10. Dahmane, N., Lee, J., Robins, P., Heller, P. & Ruiz i Altaba, A. Nature 389, 876–881 (1997).

    Article  CAS  Google Scholar 

  11. Park, H.L. et al. Development 127, 1593–1605 (2000).

    CAS  PubMed  Google Scholar 

  12. Isaacs, H. Jr. J. Pediatr. Surg. 45, 619–626 (2010).

    Article  Google Scholar 

  13. Simone, C. et al. Nat. Genet. 36, 738–743 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Jeremy F. Reiter is at the Department of Biochemistry and Biophysics, Cardiovascular Research Institute, University of California-San Francisco, San Francisco, California, USA.,

    Jeremy F Reiter

Authors
  1. Jeremy F Reiter
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jeremy F Reiter.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Reiter, J. Crippling SWI-SNF makes tumors GLI-ful. Nat Med 16, 1374–1376 (2010). https://doi.org/10.1038/nm1210-1374

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1210-1374

  • Springer Nature America, Inc.

Search

Navigation