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Quelling cholesterol pathway fends off brain damage

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A molecular pathway known for regulating cholesterol and lipid metabolism is now implicated in stroke (pages 1399–1406). The pathway is bumped up by N-methyl-D-aspartate glutamate receptors (NMDARs), which are hyperactivated in stroke and other conditions.

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Figure 1: NMDAR-mediated activation of SREBP in neuronal cells.

Kim Caesar

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Authors and Affiliations

  1. Maria T. Bengoechea-Alonso and Johan Ericsson are at the School of Medicine and Medical Science Conway Institute, University College Dublin, Belfield, Dublin, Ireland.,

    Maria T Bengoechea-Alonso & Johan Ericsson

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  1. Maria T Bengoechea-Alonso
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  2. Johan Ericsson
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Correspondence to Johan Ericsson.

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Bengoechea-Alonso, M., Ericsson, J. Quelling cholesterol pathway fends off brain damage. Nat Med 15, 1358–1359 (2009). https://doi.org/10.1038/nm1209-1358

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