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Brain inflammation initiates seizures

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Interfering with the adhesion of immune cells to the cerebral vasculature holds seizures in check, potentially opening a new realm of therapeutics (pages 1377–1383).

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Figure 1: Firing up a seizure.

Kim Caesar

References

  1. Fabene, P.F. et al. Nat. Med. 14, 1377–1383 (2008).

    Article  CAS  Google Scholar 

  2. Logroscino, G., Hesdorffer, D.C., Cascino, G. & Hauser, W.A. Arch. Neurol. 65, 221–224 (2008).

    Article  Google Scholar 

  3. Vignatelli, L., Tonon, C. & D'Alessandro, R. Epilepsia 44, 964–968 (2003).

    Article  Google Scholar 

  4. Sahin, M., Menache, C.C., Holmes, G.L. & Riviello, J.J. Epilepsia 42, 1461–1467 (2001).

    Article  CAS  Google Scholar 

  5. Fujikawa, D.G. Epilepsy Behav. 7 Suppl. 3, S3–S11 (2005).

    Article  Google Scholar 

  6. Meldrum, B.S. Prog. Brain Res. 135, 3–11 (2002).

    Article  CAS  Google Scholar 

  7. Seiffert, E. et al. J. Neurosci. 24, 7829–7836 (2004).

    Article  CAS  Google Scholar 

  8. Tomkins, O. et al. Neurobiol. Dis. 25, 367–377 (2007).

    Article  CAS  Google Scholar 

  9. Uva, L. et al. Neuroscience 151, 303–312 (2008).

    Article  CAS  Google Scholar 

  10. Cavalheiro, E.A., Naffah-Mazzacoratti, M.G., Mello, L.E. & Leite, J.P. in Models of Seizures and Epilepsy. (Eds. Pitkanen, A., Schwartzkroin, P.A. & Moshe, S.L.) 433–448 (Elsevier, Burlington, Massachusetts, 2006).

    Book  Google Scholar 

  11. Ballabh, P., Braun, A. & Nedergaard, M. Neurobiol. Dis. 16, 1–13 (2004).

    Article  CAS  Google Scholar 

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Kleen, J., Holmes, G. Brain inflammation initiates seizures. Nat Med 14, 1309–1310 (2008). https://doi.org/10.1038/nm1208-1309

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