Skip to main content
SpringerLink
Log in

Putting the heat on cancer

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Two studies highlight the role of the heat shock response in initiating and maintaining cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: HSP90 and HSF1 regulate tumor cell survival.

Kim Caesar

References

  1. Dai, C., Whitesell, L., Rogers, A.B. & Lindquist, S. Cell 130, 1005–1018 (2007).

  2. Kang, B.H. et al. Cell 131, 257–270 (2007).

    Article  CAS  Google Scholar 

  3. Powers, M.V. & Workman, P. FEBS Lett. 581, 3758–3769 (2007).

    Article  CAS  Google Scholar 

  4. Sharp, S. & Workman, P. Adv. Cancer Res. 95, 323–348 (2006).

    Article  CAS  Google Scholar 

  5. Chiosis, G. & Neckers, L. ACS Chem. Biol. 1, 279–284 (2006).

    Article  CAS  Google Scholar 

  6. Workman, P. et al. Ann. NY Acad. Sci. 1113, 202–216 (2007).

    Article  CAS  Google Scholar 

  7. Banerji, U. et al. J. Clin. Oncol. 23, 4152–4161 (2005).

    Article  CAS  Google Scholar 

  8. Hayden, P.J. et al. Curr. Opin. Hematol. 14, 609–615 (2007).

    Article  CAS  Google Scholar 

  9. Hahn, J.S. et al. Mol. Cell. Biol. 24, 5249–5256 (2004).

    Article  CAS  Google Scholar 

  10. Xiao, X. et al. EMBO J. 18, 5943–5952 (1999).

    Article  CAS  Google Scholar 

  11. Hsu, A.L. et al. Science 300, 1142–1145 (2003).

    Article  CAS  Google Scholar 

  12. Whitesell, L. & Lindquist, S.L. Nat. Rev. Cancer 5, 761–772 (2005).

    Article  CAS  Google Scholar 

  13. Gatenby, R.A. & Gillies, R.J. Nat. Rev. Cancer 4, 891–899 (2004).

    Article  CAS  Google Scholar 

  14. Plescia, J. et al. Cancer Cell 7, 457–468 (2005).

    Article  CAS  Google Scholar 

  15. Green, D.R. & Kroemer, G. Science 305, 626–629 (2004).

    Article  CAS  Google Scholar 

  16. Powers, M.V. & Workman, P. Nat. Chem. Biol. 3, 455–457 (2007).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Paul Workman and Emmanuel de Billy are in the Signal Transduction and Molecular Pharmacology Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Haddow Laboratories, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK paul.workman@icr.ac.uk,

    Paul Workman & Emmanuel de Billy

Authors
  1. Paul Workman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emmanuel de Billy
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Competing interests

P.W. has developed HSP90 inhibitors that are licensed to Vernalis and Novartis. He has received research funding from Vernalis and is a consultant to Novartis.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Workman, P., de Billy, E. Putting the heat on cancer. Nat Med 13, 1415–1417 (2007). https://doi.org/10.1038/nm1207-1415

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1207-1415

  • Springer Nature America, Inc.

Search

Navigation