Certain oncogenes seem to be able to trigger cellular senescence and growth arrest, thereby holding cancer at bay. Two new studies suggest that oncogenes trigger senescence through activation of a pathway initially described as sensing DNA damage.
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Kim Caesar
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Cao, L., Finkel, T. Cancer gets the Chk'ered flag. Nat Med 12, 1354–1356 (2006). https://doi.org/10.1038/nm1206-1354
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DOI: https://doi.org/10.1038/nm1206-1354
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