Skip to main content
SpringerLink
Log in

Antibody diversity: one enzyme to rule them all

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Three reactions diversify antibody genes in human somatic cells of the B lineage: VDJ recombination, somatic hypermutation and class-switch recombination. The discovery of activation-induced cytidine deaminase (AID) has led to the elucidation of a unified molecular mechanism for initiation of the last two reactions and suggests why B cells undergoing these reactions are prone to cancer-associated DNA damage.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Antibody diversification.

References

  1. Li, Z., Woo, C.J., Iglesias-Ussel, M.D., Ronai, D. & Scharff, M.D. Genes Dev. 18, 1–11 (2004).

    Article  Google Scholar 

  2. Chaudhuri, J. & Alt, F.W. Nat. Rev. Immunol. 4, 541–552 (2004).

    Article  CAS  Google Scholar 

  3. Muramatsu, M. et al. J. Biol. Chem. 274, 18470–18476 (1999).

    Article  CAS  Google Scholar 

  4. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    CAS  Google Scholar 

  5. Revy, P. et al. Cell 102, 565–575 (2000).

    CAS  Google Scholar 

  6. Doi, T., Kinoshita, K., Ikegawa, M., Muramatsu, M. & Honjo, T. Proc. Natl. Acad. Sci. USA 100, 2634–2638 (2003).

    Article  CAS  Google Scholar 

  7. Petersen-Mahrt, S.K., Harris, R.S. & Neuberger, M.S. AID Nature 418, 99–103 (2002).

    Article  CAS  Google Scholar 

  8. Bransteitter, R., Pham, P., Scharff, M.D. & Goodman, M.F. Proc. Natl. Acad. Sci. 100 4102–4107 (2003).

    Article  CAS  Google Scholar 

  9. Chaudhuri, J. et al. Nature 422, 726–730 (2003).

    Article  CAS  Google Scholar 

  10. Dickerson, S.K., Market, E., Besmer, E. & Papavasiliou, F.N. J. Exp. Med. 197, 1291–1296 (2003).

    Article  CAS  Google Scholar 

  11. Ramiro, A.R., Stavropoulos, P., Jankovic, M. & Nussenzweig, M.C. Nat. Immunol. 4, 452–456 (2003).

    Article  CAS  Google Scholar 

  12. Pham, P., Bransteitter, R., Petruska, J. & Goodman, M.F. Nature 424, 103–7 (2003).

    Article  CAS  Google Scholar 

  13. Nambu, Y. et al. Science 302, 2137–2140 (2003).

    Article  CAS  Google Scholar 

  14. Chaudhuri, J., Khuong, C. & Alt, F.W. Nature 430, 992–998 (2004).

    Article  CAS  Google Scholar 

  15. Imai, K. et al. Nat. Immunol. 4, 1023–1028 (2003).

    Article  CAS  Google Scholar 

  16. Rada, C., Di Noia, J.M. & Neuberger, M.S. Mol. Cell 16, 163–171 (2004).

    Article  CAS  Google Scholar 

  17. Fernandez-Capetillo, O., Lee, A., Nussenzweig, M. & Nussenzweig, A. DNA Repair 3, 959–967 (2004).

    Article  CAS  Google Scholar 

  18. Bassing, C.H. & Alt, F.W. DNA Repair (Amst) 3, 781–796 (2004).

    Article  CAS  Google Scholar 

  19. Petersen, S. et al. Nature 414, 660–665 (2001).

    Article  CAS  Google Scholar 

  20. Reina-San-Martin, B. et al. J. Exp. Med. 197, 1767–1778 (2003).

    Article  CAS  Google Scholar 

  21. Pasqualucci, L. et al. Nature 412, 341–346 (2001).

    Article  CAS  Google Scholar 

  22. Shen, H.M., Peters, A., Baron, B., Zhu, X. & Storb, U. Science 280, 1750–1752 (1998).

    Article  CAS  Google Scholar 

  23. Müschen, M. et al. J. Exp. Med. 192, 1833–1840 (2000).

    Article  Google Scholar 

  24. Okazaki, I.M. et al. J. Exp. Med. 197, 1173–1181 (2003).

    Article  CAS  Google Scholar 

  25. Unniraman, S., Zhou, S. & Schatz, D.G. Nat. Immunol. 5, 1117–1123 (2004).

    Article  CAS  Google Scholar 

  26. Ramiro, A.R. et al. Cell 118, 431–438 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Molecular Immunology and the Howard Hughes Medical Institute, The Rockefeller University, New York, 10021, New York, USA

    Michel C Nussenzweig

  2. The Center for Blood Research and Department of Genetics, Howard Hughes Medical Institute, The Children's Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA

    Frederick W Alt

Authors
  1. Michel C Nussenzweig
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Frederick W Alt
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nussenzweig, M., Alt, F. Antibody diversity: one enzyme to rule them all. Nat Med 10, 1304–1305 (2004). https://doi.org/10.1038/nm1204-1304

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1204-1304

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation