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Protecting the host naturally

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A new approach to hematopoietic cell transplantation in people seems to lessen the incidence of a serious complication, acute graft-versus-host disease.

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Figure 1: In animal models, conditioning with total lymphoid irradiation and antithymocyte globulin led to marked depletion of 'conventional' T cells in the lymphoid tissues, with enrichment for NKT cells, which are relatively radioresistant.

Katie Ris

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Authors and Affiliations

  1. Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, Massachusetts, USA

    Megan Sykes

  2. Bone Marrow Transplant Unit, Massachusetts General Hospital, Harvard Medical School, Boston, 02129, Massachusetts, USA

    Thomas R Spitzer

Authors
  1. Megan Sykes
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  2. Thomas R Spitzer
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Sykes, M., Spitzer, T. Protecting the host naturally. Nat Med 11, 1164–1165 (2005). https://doi.org/10.1038/nm1105-1164

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