Skip to main content

Advertisement

SpringerLink
Log in

Cancer: the matrix is now in control

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

The extracellular matrix is traditionally regarded as a facilitator of tumor progression, providing an environment in which cells can grow and metastasize. Three new studies take the matrix out of this context and suggest that the microenvironment can not only subsidize, but also initiate, the oncogenic conversion of epithelial cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: The tumor microenvironment can drive the onset of cancer.

Katie Ris

References

  1. Giancotti, F.G. & Tarone, G. Annu. Rev. Cell. Dev. Biol. 19, 173–206 (2003).

    Article  CAS  Google Scholar 

  2. Hanahan, D. & Weinberg, R.A. Cell 100, 57–70 (2000).

    Article  CAS  Google Scholar 

  3. Radisky, D.C. et al. Nature 436, 123–127 (2005).

    Article  CAS  Google Scholar 

  4. List, K. et al. Genes Dev. 19, 1934–1950 (2005).

    Article  CAS  Google Scholar 

  5. Paszek, M.J. et al. Cancer Cell 8, 241–254 (2005).

    Article  CAS  Google Scholar 

  6. Overall, C.M. & López-Otín, C. Nat. Rev.Cancer 2, 657–672 (2002).

    Article  CAS  Google Scholar 

  7. Egeblad, M. & Werb, Z. Nat. Rev. Cancer 2, 163–176 (2002).

    Article  Google Scholar 

  8. Sternlicht, M.D. et al. Cell 98, 137–146 (1999).

    Article  CAS  Google Scholar 

  9. Benaud, C.M, Oberst, M., Dickson, R.B. & Lin, C.Y. Clin. Exp. Metastasis 19, 639–649 (2002).

    Article  CAS  Google Scholar 

  10. Lee, S.L., Dickson, R.B. & Lin, C.Y. J. Biol. Chem. 275, 36720–36725 (2000).

    Article  CAS  Google Scholar 

  11. Trusolino, L. & Comoglio, P.M. Nat. Rev. Cancer 2, 289–300 (2002).

    Article  CAS  Google Scholar 

  12. Noonan, F.P, Otsuka, T., Bang, S., Anver, M.R. & Merlino, G. Cancer Res. 60, 3738–3743 (2000).

    CAS  Google Scholar 

  13. O'Brien, L.E., Zegers, M.M. & Mostov, K.E. Nat. Rev. Mol. Cell. Biol. 3, 531–537 (2002).

    Article  CAS  Google Scholar 

  14. Coussens, L.M. & Werb, Z. Nature 420, 860–867 (2002).

    Article  CAS  Google Scholar 

  15. Boccaccio, C. et al. Nature 434, 396–400 (2005).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Molecular Oncology, IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy

    Paolo M Comoglio & Livio Trusolino

Authors
  1. Paolo M Comoglio
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Livio Trusolino
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Comoglio, P., Trusolino, L. Cancer: the matrix is now in control. Nat Med 11, 1156–1158 (2005). https://doi.org/10.1038/nm1105-1156

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1105-1156

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation