Hematopoietic stem cells maintain the capacity for self-renewal despite the hazard of oxidative damage. Studies in mice show that this hazard is held in check by the ataxia telangiectasia mutated gene, operating through some well-known tumor suppressors.
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Michael Pace
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Whetton, A. Stem cells bank on ATM machine. Nat Med 10, 1166–1168 (2004). https://doi.org/10.1038/nm1104-1166
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DOI: https://doi.org/10.1038/nm1104-1166
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