M. tuberculosis persists in the body, sequestered inside macrophages and subverting the phagocytic machinery to create a membrane-bound home. Microarray profiling studies reveal how the bacterium settles into its new environment.
References
Armstrong, J.A. & Hart, P.D. J. Exp. Med. 134, 713–740 (1971).
Schnappinger, D. et al. J. Exp. Med. 198, 693–704 (2003).
Voskuil, M.I. J. Exp. Med. 198, 705–713 (2003).
MacMicking, J.D. et al. Proc. Natl. Acad. Sci. USA 94, 5243–5248 (1997).
MacMicking, J.D., Taylor, G.A. & McKinney, J.D. Science (in the press).
Fisher, M.A., Plikaytis, B.B. & Shinnick, T.M. J. Bacteriol. 184, 4025–4032 (2002).
Dye, C. et al. JAMA 282, 677–686 (1999).
Flynn, J.L. & Chan, J. Infect. Immun. 69, 4195–4201 (2001).
Shi, L. et al. Proc. Natl. Acad. Sci. USA 100, 241–246 (2003).
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McKinney, J., Gomez, J. Life on the inside for Mycobacterium tuberculosis. Nat Med 9, 1356–1357 (2003). https://doi.org/10.1038/nm1103-1356
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DOI: https://doi.org/10.1038/nm1103-1356
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