Skip to main content
SpringerLink
Log in

Setting fat on fire

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

One approach to developing antiobesity drugs is to shift the energy balance in the body in favor of burning fat. A transcriptional coactivator is now assigned this task.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Control of fatty acid oxidation and thermogenesis by nuclear receptors and their coactivators.

Renee Lucas

References

  1. Kamei et al. Proc. Natl. Acad. Sci. USA (in the press).

  2. Andersson, U. & Scarpulla, R.C. Mol. Cell. Biol. 21, 3738–3749 (2001).

    Article  CAS  Google Scholar 

  3. Puigserver, P. et al. Cell 92, 829–839 (1998).

    Article  CAS  Google Scholar 

  4. Lin, J., Puigserver, P., Donovan, J., Tarr, P. & Spiegelman, B.M. J. Biol. Chem. 277, 1645–1648 (2002).

    Article  CAS  Google Scholar 

  5. Yoon, J.C. et al. Nature 413, 131–138 (2001).

    Article  CAS  Google Scholar 

  6. Lin, J. et al. Nature 418, 797–801 (2002).

    Article  CAS  Google Scholar 

  7. St-Pierre, J. et al. J. Biol. Chem. 278, 26597–26603 (2003).

    Article  CAS  Google Scholar 

  8. Sladek, R., Bader, J. & Giguere, V. Mol. Cell. Biol. 17, 5400–5409 (1997).

    Article  CAS  Google Scholar 

  9. Huss, J.M., Kopp, R.P. & Kelly, D.P. J. Biol. Chem. 277, 40265–40274 (2002).

    Article  CAS  Google Scholar 

  10. Schreiber, S.N., Knutti, D., Brogli, K., Uhlmann, T. & Kralli, A. J. Biol. Chem. 278, 9013–9018 (2003).

    Article  CAS  Google Scholar 

  11. Wang, Y.X. et al. Cell 113, 159–170 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, 90095-1662, California, USA

    Robert Walczak & Peter Tontonoz

Authors
  1. Robert Walczak
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Peter Tontonoz
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Walczak, R., Tontonoz, P. Setting fat on fire. Nat Med 9, 1348–1349 (2003). https://doi.org/10.1038/nm1103-1348

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1103-1348

  • Springer Nature America, Inc.

This article is cited by

Search

Navigation