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It's what you do with the fat that matters!

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Obesity and a diet rich in saturated fatty acids can lead to high lipid levels in the liver and insulin resistance. However, inhibition of a key enzyme that elongates long-chain saturated fatty acids can protect against insulin resistance in fatty livers, even with concurrent obesity (pages 1193–1202).

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Figure 1: Loss of Elovl6 leads to improved insulin signaling even in fatty livers.

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Authors and Affiliations

  1. Diabetes and Metabolism Division, Clinton R. Bruce and Mark A. Febbraio are in the Cellular and Molecular Metabolism Laboratory, Baker Heart Research Institute, Melbourne, Victoria 3004, Australia. mark.febbraio@baker.edu.au,

    Clinton R Bruce & Mark A Febbraio

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  1. Clinton R Bruce
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  2. Mark A Febbraio
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Bruce, C., Febbraio, M. It's what you do with the fat that matters!. Nat Med 13, 1137–1138 (2007). https://doi.org/10.1038/nm1007-1137

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