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Controlling angiogenesis in heart valves

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Thickening of the cardiac valves leads to congestive heart failure, chest pain, sudden loss of consciousness and often death. Experiments in mice now link this condition to dysregulation of an endogenous inhibitor of angiogenesis (1151–1159).

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Figure 1: Chondromodulin-I maintains a state of avascularity in healthy cardiac valves.

Kim Caesar

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Authors and Affiliations

  1. Division of Matrix Biology, Department of Medicine, Dana 514, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, 02215, Massachusetts, USA

    Raghu Kalluri & Elisabeth Zeisberg

  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 77 Massachusetts Avenue, Boston, 02115, Massachusetts, USA

    Raghu Kalluri & Elisabeth Zeisberg

  3. Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology, 240 Longwood Avvenue, Cambridge, 02139, Massachusetts, USA

    Raghu Kalluri & Elisabeth Zeisberg

Authors
  1. Raghu Kalluri
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  2. Elisabeth Zeisberg
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Kalluri, R., Zeisberg, E. Controlling angiogenesis in heart valves. Nat Med 12, 1118–1119 (2006). https://doi.org/10.1038/nm1006-1118

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