Clinical transplants of hematopoietic stem cells have a large spectrum of therapeutic applications, but these can be limited by insufficient stem cell numbers and the current inability to expand them in vitro. Inactivation of an enzyme that impedes stem-cell homing to the bone marrow may offer a simple alternative.
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Eaves, C. Hematopoietic stem cells get closer to the bone. Nat Med 10, 1042–1044 (2004). https://doi.org/10.1038/nm1004-1042
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DOI: https://doi.org/10.1038/nm1004-1042
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