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The new immunosuppression: just kill the T cell

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Antibodies to the CD40 ligand have modulated the immune system in animal experiments and in human clinical trials. Assumptions about how these antibodies work are now reexamined (pages 1275–1280).

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Figure 1: CD40L and tolerance: proposed mechanism by which CD40L antibody therapy induces dominant tolerance when associated with transplanted tissue grafts, and deletional tolerance when combined with substantial infusions of donor bone marrow cells.

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  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Herman Waldmann

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  1. Herman Waldmann
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Waldmann, H. The new immunosuppression: just kill the T cell. Nat Med 9, 1259–1260 (2003). https://doi.org/10.1038/nm1003-1259

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