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Tumors hijack fetal enzyme, escape killer T cells

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During pregnancy, tryptophan degradation in the placenta protects a growing fetus from attack by T cells. Tumor cells are now shown to exploit this unusual system to prevent rejection by tumor-specific cytotoxic T cells (pages 1269–1274).

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Figure 1: IDO as a T-cell contraceptive.

Kimberly Homer

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Authors and Affiliations

  1. Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands

    Koen Schepers & Ton N M Schumacher

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  1. Koen Schepers
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  2. Ton N M Schumacher
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Schepers, K., Schumacher, T. Tumors hijack fetal enzyme, escape killer T cells. Nat Med 9, 1253–1254 (2003). https://doi.org/10.1038/nm1003-1253

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