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Modulating autoimmunity: pick your PI3 kinase

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Small molecules that specifically inhibit PI3Kγ block disease in mouse models of arthritis and lupus (pages 936–943).

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Figure 1: New, selective inhibitors preferentially block GPCR-coupled activation of PI3Kγ.

Katie Ris

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Authors and Affiliations

  1. Ontario Cancer Institute, Toronto, M5G 2M9, Ontario

    Pamela S Ohashi

  2. Campbell Family Institute for Breast Cancer Research, Toronto, M5C 2M1, Ontario, Canada

    Pamela S Ohashi

  3. Ontario Cancer Institute, Toronto, M5G 2M9, Ontario, Canada

    James R Woodgett

Authors
  1. Pamela S Ohashi
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  2. James R Woodgett
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Ohashi, P., Woodgett, J. Modulating autoimmunity: pick your PI3 kinase. Nat Med 11, 924–925 (2005). https://doi.org/10.1038/nm0905-924

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