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Senescence comes of age

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Normal cells can respond to expression of activated oncogenes by initiating cellular senescence, a permanent state of proliferative arrest. But whether this process reflects a relevant anticancer mechanism has been debated. Several studies now show that oncogene-induced senescence can occur in vivo and provides a bona fide barrier to tumorigenesis.

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Figure 1: Oncogene-induced senescence in vivo.

Katie Ris

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Authors and Affiliations

  1. Cold Spring Harbor Laboratory and Scott W. Lowe is also at the Howard Hughes Medical Institute, Cold Spring Harbor, 11724, New York, USA

    Masashi Narita & Scott W Lowe

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  1. Masashi Narita
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  2. Scott W Lowe
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Narita, M., Lowe, S. Senescence comes of age. Nat Med 11, 920–922 (2005). https://doi.org/10.1038/nm0905-920

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