Neuropathic pain syndromes such as phantom limb pain have remained enigmatic to patients, physicians and researchers alike. A new study reveals how nerve damage may alter the pain threshold and lead to such syndromes.
References
Coull et al., Trannsynaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain. Nature 424, 938–942 (2003).
Bennett, G.J. & Xie, Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33, 87–107 (1988).
Woolf, C.J. & Salter, M.W. Neuronal plasticity: increasing the gain in pain. Science 288, 1765–1769 (2000).
Ganguly, K., Schinder, A.F., Wong, S.T. & Poo, M. GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition. Cell 105, 521–532 (2001).
van den Pol, A.N., Obrietan, K. & Chen, G. Excitatory actions of GABA after neuronal trauma. J. Neurosci. 16, 4283–4292 (1996).
Jonas, P., Bischofberger, J. & Sandkuhler, J. Corelease of two fast neurotransmitters at a central synapse. Science 281, 360–361 (1998).
Gao, B.X., Stricker, C. & Ziskind-Conhaim, L. Transition from GABAergic to glycinergic synaptic transmission in newly formed spinal networks. J. Neurophysiol. 86, 492–502 (2001).
Lim, R., Alvarez, F.J. & Walmsley, B. GABA mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus. J. Physiol. 525, 447–459 (2000).
Sivilotti, L. & Woolf, C.J. The contribution of GABAA and glycine receptors to central sensitization: disinhibition and touch-evoked allodynia in the spinal cord. J. Neurophysiol. 72, 169–179 (1994).
Cohen, I., Navarro, V., Clemenceau, S., Baulac, M. & Miles, R. On the origin of interictal activity in human temporal lobe epilepsy in vitro. Science 298, 1418–1421 (2002).
Titz, S. et al. Hyperpolarizing inhibition develops without trophic support by GABA in cultured rat midbrain neurons. J. Physiol. (Lond.) 550, 719–730 (2003).
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Staley, K. Salt and wounds: a new mechanism for neuropathic pain. Nat Med 9, 1110–1111 (2003). https://doi.org/10.1038/nm0903-1110
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DOI: https://doi.org/10.1038/nm0903-1110
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