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Planting new targets for antiparasitic drugs

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An organelle in apicomplexan parasites including those causing malaria and toxoplasmosis may be the site of a plant biosynthetic pathway that could provide new targets for drug discovery and development.

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References

  1. Fichera, M.E. & Roos, D.S. A plastid organdie as a drug target in apicomplexan parasites. Nature 390, 407–409 (1997).

    Article  CAS  Google Scholar 

  2. Wilson, R.J.M. et al. Complete gene map of the plastid-like DNA of the malaria parasite Plasmodium falciparum. J. Mol. Biol. 261, 155–172 (1996).

    Article  CAS  Google Scholar 

  3. Köhler, S. et al. A plastid of probable green algal origin in apicomplexan parasites. Science 275, 1485–1489 (1997).

    Article  Google Scholar 

  4. Roberts, F. et al. Evidence for shikimate pathway in apicomplexan parasites. Nature 393, 801–805 (1998).

    Article  CAS  Google Scholar 

  5. Bentley, R. The shikimate pathway—a metabolic tree with many branches. Crit. Rev. Biochem. Mol. Biol. 25, 307–383 (1990).

    Article  CAS  Google Scholar 

  6. McFadden, G.I., Reith, M.E., Munholland, J. & Lang-Unnasch, N. Plastid in human parasites. Nature 381, 482 (1996).

    Article  CAS  Google Scholar 

  7. Ridley, R.G. Antimalarial drug discovery and development—an industrial perspective. Exptl. Parasitol. 87, 293–304 (1997).

    Article  CAS  Google Scholar 

  8. Lill R., Nargang F.E. & Neupert W. Biogenesis of mitochondrial proteins. Curr. Opin. Cell Biol. 8, 505–512 (1996).

    Article  CAS  Google Scholar 

  9. Hrazdina, C. & Jensen, R.R. Spatial organisation of enzymes in plant metabolic pathways. Annu. Rev. Plant Physiol. Plant Mol. Biol. 43, 241 (1992).

    Article  CAS  Google Scholar 

  10. Donald, R.G.K. & Roos, D.S. Gene knock-outs and allelic replacements in Toxoplasma gondii: HXGPRT as a selectable marker for ‘hit and run’ mutagenesis. Mol. Biochem. Parasitol. 91, 295–305 (1998).

    Article  CAS  Google Scholar 

  11. Crabb, B.S. et al. Targeted gene disruption shows that knobs enable malaria infected red cells to cytoadhere under physiological conditions. Cell 89, 287–296 (1997).

    Article  CAS  Google Scholar 

  12. Ajioka, J. et al. Gene discovery by EST sequencing in Toxoplasma gondii reveals sequences restricted to the apicomplexa. Genome Research 8, 18–28 (1998)

    Article  CAS  Google Scholar 

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  1. Pharma Research, Preclinical Infectious Diseases, F. Hoffmann-La Roche, CH-4070, Basel, Switzerland

    Robert G. Ridley

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  1. Robert G. Ridley
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Ridley, R. Planting new targets for antiparasitic drugs. Nat Med 4, 894–895 (1998). https://doi.org/10.1038/nm0898-894

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