Cancers can compromise the capacity of the host immune system to recognize tumor antigens. Recent findings now show that increased accumulation of lipids in dendritic cells in tumors can impair presentation of tumor antigens—which is crucial for activation of the immune system—providing a conceptual framework that may help increase the efficacy of therapeutic vaccines (pages 880–886).
References
Smyth, M.J., Dunn, G.P. & Schreiber, R.D. Adv. Immunol. 90, 1–50 (2006).
Zitvogel, L., Tesniere, A. & Kroemer, G. Nat. Rev. Immunol. 6, 715–727 (2006).
Zitvogel, L. et al. J. Clin. Invest. 118, 1991–2001 (2008).
Herber, D.L. et al. Nat. Med. 16, 880–886 (2010).
Steinman, R.M. & Banchereau, J. Nature 449, 419–426 (2007).
Yi, H. et al. Blood 113, 5819–5828 (2009).
Beckers, A. et al. Cancer Res. 67, 8180–8187 (2007).
Menendez, J.A. & Lupu, R. Nat. Rev. Cancer 7, 763–777 (2007).
Little, J.L., Wheeler, F.B., Fels, D.R., Koumenis, C. & Kridel, S.J. Cancer Res. 67, 1262–1269 (2007).
Panaretakis, T. et al. Cell Death Differ. 15, 1499–1509 (2008).
Ramakrishnan, R. et al. J. Clin. Invest. 120, 1111–1124 (2010).
Zitvogel, L., Apetoh, L., Ghiringhelli, F. & Kroemer, G. Nat. Rev. Immunol. 8, 59–73 (2008).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Zitvogel, L., Kroemer, G. Targeting dendritic cell metabolism in cancer. Nat Med 16, 858–859 (2010). https://doi.org/10.1038/nm0810-858
Issue Date:
DOI: https://doi.org/10.1038/nm0810-858
- Springer Nature America, Inc.