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Streptococcus pyogenes under pressure

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Contemporary M1 strains of Streptococcus pyogenes have acquired a DNase gene that improves the virulence of the bacterium, but its expression is repressed by the CovRS regulatory system. Walker et al. report that the bacteria are under selective pressure to mutate the covRS locus to maintain DNase expression for invasive infection (pages 982–986).

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Figure 1: Model explaining mutation of Streptococcus pyogenes regulatory locus during invasive infection.

Katie Ris-Vicari

References

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Authors and Affiliations

  1. Claire Turner and Shiranee Sriskandan are in the Department of Infectious Diseases & Immunity, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK. s.sriskandan@imperial.ac.uk,

    Claire Turner & Shiranee Sriskandan

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  1. Claire Turner
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  2. Shiranee Sriskandan
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The authors declare no competing financial interests.

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Turner, C., Sriskandan, S. Streptococcus pyogenes under pressure. Nat Med 13, 909–910 (2007). https://doi.org/10.1038/nm0807-909

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