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Rosacea: skin innate immunity gone awry?

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Rosacea is a common skin disorder marked by chronic inflammation and vascular abnormalities. Two new features of the skin lesions have been identified: elevated levels of cathelicidin antimicrobial peptides and of a related serine protease. These molecules of innate immunity may represent key elements of pathogenesis, as well as new targets for effective therapies (pages 975–981).

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Figure 1: Rosacea and proteolytic processing of cathelicidin peptides.

Katie Ris-Vicari

References

  1. Buechner, S.A. Dermatology 210, 100–108 (2005).

    Article  Google Scholar 

  2. Crawford, G.H., Pelle, M.T. & James, W.D. J. Am. Acad. Dermatol. 51, 327–341 (2004).

    Article  Google Scholar 

  3. Neumann, E. & Frithz, A. Int. J. Dermatol. 37, 263–266 (1998).

    Article  CAS  Google Scholar 

  4. Fredricks, D.N. J. Investig. Dermatol. Symp. Proc. 6, 167–169 (2001).

    Article  CAS  Google Scholar 

  5. Yamasaki, K. et al. Nat. Med. 13, 975–981 (2007).

    Article  CAS  Google Scholar 

  6. Nizet, V. et al. Nature 414, 454–457 (2001).

    Article  CAS  Google Scholar 

  7. Zanetti, M. Curr. Issues Mol. Biol. 7, 179–196 (2005).

    CAS  PubMed  Google Scholar 

  8. Ong, P.Y. et al. N. Engl. J. Med. 347, 1151–1160 (2002).

    Article  CAS  Google Scholar 

  9. Chung, W.O., Hansen, S.R., Rao, D. & Dale, B.A. J. Immunol. 173, 5165–5170 (2004).

    Article  CAS  Google Scholar 

  10. Asokananthan, N. et al. J. Immunol. 169, 4572–4578 (2002).

    Article  CAS  Google Scholar 

  11. Brown, A. et al. Am. J. Respir. Cell Mol. Biol. 29, 381–389 (2003).

    Article  CAS  Google Scholar 

  12. Koczulla, R. et al. J. Clin. Invest. 111, 1665–1672 (2003).

    Article  CAS  Google Scholar 

  13. Acharya, M.R., Venitz, J., Figg, W.D. & Sparreboom, A. Drug Resist. Updat. 7, 195–208 (2004).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Charles L. Bevins is in the Departments of Microbiology and Immunology, School of Medicine, and Graduate Group in Immunology, University of California, Davis, California 95616, USA. clbevins@ucdavis.edu,

    Charles L Bevins

  2. Fu-Tong Liu is in the Department of Dermatology, School of Medicine, and Graduate Group in Immunology, University of California, Sacramento, California 95817, USA. fliu@ucdavis.edu,

    Fu-Tong Liu

Authors
  1. Charles L Bevins
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  2. Fu-Tong Liu
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The authors declare no competing financial interests.

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Bevins, C., Liu, FT. Rosacea: skin innate immunity gone awry?. Nat Med 13, 904–906 (2007). https://doi.org/10.1038/nm0807-904

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