Skip to main content
Log in

Type 1 diabetes: focus on prevention

  • News & Views
  • Published:

From Nature Medicine

View current issue Submit your manuscript

Two new approaches prevent disease in a model of type 1 diabetes. One approach blocks an activation receptor on disease-conferring T cells. The second deploys suppressor T cells renowned for their ability to inhibit the local immune response.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Protecting the islet.

Deborah Maizels

References

  1. Ogasawara, K. et al. Immunity 20, 757–767 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Tang, Q. et al. J. Exp. Med. 199, 1455–1465 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Tarbell, K.V., Yamazaki, S., Olson, K., Toy, P. & Steinman, R.M. J. Exp. Med. 199, 1467–1477 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Khattri, R., Cox, T., Yasayko, S.A. & Ramsdell, F. Nat. Immunol. 4, 337–342 (2003).

    Article  CAS  PubMed  Google Scholar 

  5. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. J. Immunol. 155, 1151–1164 (1995).

    CAS  PubMed  Google Scholar 

  6. Bruder, D. et al. Eur. J. Immunol. 34, 623–630 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Fontenot, J.D., Gavin, M.A. & Rudensky, A.Y. Nat. Immunol. 4, 330–336 (2003).

    Article  CAS  PubMed  Google Scholar 

  8. Hori, S., Nomura, T. & Sakaguchi, S. Science 299, 1057–1061 (2003).

    Article  CAS  PubMed  Google Scholar 

  9. Jordan, M.S. et al. Nat Immunol. 2, 301–306 (2001).

    Article  CAS  PubMed  Google Scholar 

  10. Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Nat. Immunol. 3, 756–763 (2002).

    Article  CAS  PubMed  Google Scholar 

  11. Apostolou, I. & von Boehmer, H. J. Exp. Med. 199, 1401–1408 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. von Boehmer, H. J. Exp. Med. 198, 845–849 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Shevach, E.M. Nat. Rev. Immunol. 2, 389–400 (2002).

    Article  CAS  PubMed  Google Scholar 

  14. Herman, A.E., Freeman, G.J., Mathis, D. & Benoist, C. J. Exp. Med. 199, 1479–1489 (2004).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Daniel, D. & Wegmann, D.R. Proc. Natl. Acad. Sci. USA 93, 956–960 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Diabetes Prevention Trial—Type 1 Diabetes Study Group. N. Engl. J. Med. 346, 1685–1691 (2002).

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

von Boehmer, H. Type 1 diabetes: focus on prevention. Nat Med 10, 783–784 (2004). https://doi.org/10.1038/nm0804-783

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0804-783

  • Springer Nature America, Inc.

This article is cited by

Navigation