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Anthrax delivers a lethal blow to host immunity

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Anthrax toxin is known to impair key signaling pathways, but exactly how does this damage the body or benefit the bacterium? Impairment of host immunity is now linked to an enzymatic activity of the toxin.

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Figure 1: Anthrax toxin action at the subcellular level.

References

  1. Agrawal, A. et al. Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin. Nature 424, 329–334 (2003).

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Authors and Affiliations

  1. Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, 02115, Massachusetts, USA

    Michael N Starnbach & R John Collier

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  1. Michael N Starnbach
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  2. R John Collier
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Starnbach, M., Collier, R. Anthrax delivers a lethal blow to host immunity. Nat Med 9, 996–997 (2003). https://doi.org/10.1038/nm0803-996

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